»Whereas decreased phosphorylation of AMPK and modulation of a series of downstream events leading to fatty acid synthesis and lipogenesis were observed in rat hepatocytes and human hepatoma cell lines, mouse hepatocytes were resistant to OA with regard to the AMPK/SREBP-1-dependent lipogenic pathway. Similar results were observed in animal studies using SD rats and C57BL/6 mice. These two species showed completely different responses to OA in terms of AMPK/SREBP-1 signaling and development of steatosis, indicating that not only pharmacokinetic but also pharmacodynamic factors participate in determining interspecies differences.«
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